Leishmaniasis, Chagas disease and Human African Trypanosomiasis revisited: Disease Control Priorities in Developing Countries

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Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis

The trypanosomatids Trypanosoma cruzi, Leishmania spp. and Trypanosoma brucei spp. cause Chagas disease, leishmaniasis and human African trypanosomiasis, respectively. It is estimated that over 10 million people worldwide suffer from these neglected diseases, posing enormous social and economic problems in endemic areas. There are no vaccines to prevent these infections and chemotherapies are n...

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American Trypanosomiasis (Chagas Disease)

American trypanosomiasis (Chagas disease) is an important cause of human heart disease, megaesophagus and megacolon in Latin America, where the causative organism, Trypanosoma cruzi, is endemic. While this organism occasionally causes an acute illness, most people do not realize they are infected until several years or decades later, when some develop a chronic medical condition. Antiparasitic ...

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WHO | Chagas disease (American trypanosomiasis)

An estimated 10 million people are infected with Trypanosoma cruzi (the parasite that causes Chagas disease) worldwide, mostly in Latin America. Chagas disease was once entirely confined to the Region of the Americas – principally Latin America – but it has now spread to other continents. Chagas disease is curable if treatment is initiated soon after infection. Up to 30% of chronically infected...

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human african trypanosomiasis a neglected disease

Typology There are two forms of HAT, one of which is endemic mainly in East Africa and is caused by Trypanosoma brucei rhodesiense. This form represents less than 10% of the reported cases of sleeping sickness. The other form is endemic mainly in West and Central Africa and is caused by Trypanosoma brucei gambiense. This form represents more than 90% of the reported cases in Africa. These proto...

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ژورنال

عنوان ژورنال: Tropical Medicine and International Health

سال: 2006

ISSN: 1360-2276,1365-3156

DOI: 10.1111/j.1365-3156.2006.01715.x